Put these in /etc/sysctl.conf then run sysctl -p to apply them. 

# General gigabit tuning:
net.core.rmem_max = 16777216
net.core.wmem_max = 16777216
net.ipv4.tcp_rmem = 4096 87380 16777216
net.ipv4.tcp_wmem = 4096 65536 16777216
net.ipv4.tcp_syncookies = 1

# this gives the kernel more memory for tcp
# which you need with many (100k+) open socket connections
net.ipv4.tcp_mem = 50576   64768   98152
net.core.netdev_max_backlog = 2500

# if masquerading used
net.ipv4.netfilter.ip_conntrack_max = 1048576


# one million connections

net.core.rmem_max = 33554432
net.core.wmem_max = 33554432
net.ipv4.tcp_rmem = 4096 16384 33554432
net.ipv4.tcp_wmem = 4096 16384 33554432
net.ipv4.tcp_mem = 786432 1048576 26777216
net.ipv4.tcp_max_tw_buckets = 360000
net.core.netdev_max_backlog = 2500
vm.min_free_kbytes = 65536
vm.swappiness = 0
net.ipv4.ip_local_port_range = 1024 65535
